
Principal Investigator
Yixuan (Axe) Xie is an Assistant Professor and Principal Investigator at the School of Basic Medical Sciences, Adjunct Assistant Professor, Fudan SANS Neuroscience Center, Fudan University;. He received B.S. (honors) in Chemistry from Lanzhou University (2015) and received a Ph.D. in Chemistry from the University of California, Davis (2020), followed by postdoctoral and research work at the University of Pennsylvania Perelman School of Medicine and Washington University School of Medicine in St. Louis. From 2024 to 2026, he served as a Young Investigator at the Fudan University Greater Bay Area Institute of Precision Medicine, and since 2026 has been an Assistant Professor and Principal Investigator at the School of Basic Medical Sciences, Fudan University. He currently serves as a China Young Representative of the Asia-Oceania Mass Spectrometry Conference (AOMSC).
GlycoXie lab focuses on innovating multi-omics technologies centered on biological mass spectrometry, aiming to decipher the structure, quantity, and function of complex modifications on nucleic acids and proteins, with a particular emphasis on biological glycosylation. Current work centers on the discovery and functional characterization of a novel class of glycosylated RNA (glycoRNA). Related findings have been published in journals including Cell, Nature, PNAS, Nature Communications, Protein & Cell, JACS Au, and Analytical Chemistry. He honors include the Chinese American Society for Mass Spectrometry (CASMS) Young Investigator Award, the American Chemical Society (ACS) Rising Star Award, and the Royal Society of Chemistry (RSC) Emerging Investigators.
1. Deciphering the structure and function of novel glycosylated RNA (glycoRNA) biomolecules.
2. Identification and construction of glycan-mediated protein interaction networks.
3. Characterization of nucleic acid and protein modifications.
Li Yi; Yitong Zhou; Chi Zhang; Haojie Lu; Yixuan Xie, GlycoRNA research: from unknown unknowns to known unknowns, Protein & Cell, 2026, 17(2):93-112 (last corresponding author / 最后通讯作者).
Wei Cao; Zehui Yang; Chi Zhang; Li Yi; Yulong Miao; Shuyang Zhao; Cheng Yu; Xiaoman Zhou; Ting Li; Yao Zhou; Tiantian Lu; Yajing Zhang; Yue Dou; Morihisa Fujita; Yixuan Xie; Yishi Liu; Ran Xie, Lysosomal Aspartylglucosaminidase Couples Glycoprotein Catabolism to Cell-Surface GlycoRNA Production, bioRxiv, 2026 (co-corresponding author / 共同通讯作者).
Yixuan Xie; Xingyu Liu; Li Yi; Shunyang Wang; Zongtao Lin; Chenfeng Zhao; Siyu Chen; Faith M. Robison; Benson M. George; Carlito B. Lebrilla; Ryan A. Flynn; Benjamin A. Garcia, Development and application of GlycanDIA workflow for glycomic analysis, Nature Communications, 2025, 16:7075 (sole first author, co-corresponding author / 唯一第一作者,共同通讯作者).
Xingyu Liu; Li Yi; Zongtao Lin; Siyu Chen; Shunyang Wang; Ying Sheng; Carlito B. Lebrilla; Benjamin A. Garcia; Yixuan Xie, Metabolic Control of Glycosylation Forms for Establishing Glycan-Dependent Protein Interaction Networks, Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2025, 122(25): e2422936122 (last corresponding author / 最后通讯作者).
Yixuan Xie; Peiyuan Chai; Nicholas A. Till; Helena Hemberger; Charlotta G. Lebedenko; Jennifer Porat; Christopher P. Watkins; Reese M. Caldwell; Benson M. George; Jonathan Perr; Carolyn R. Bertozzi; Benjamin A. Garcia; Ryan A. Flynn, The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA, Cell, 2024, 187(19):5228-5237 (co-first author, first / 共同第一作者,第一).
Address: Research Building 2, 130 Dongan Road, Xuhui District, Shanghai, China
Postal Code: 200032
Email: axexie@fudan.edu.cn
Lab Website: https://glycoxielab.org